Publications


Publications
Publications

Broughton KM, Sussman MA Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells. Circ. Res. 2018 Jul 06 123(2):177-187.

Broughton KM, Wang BJ, Firouzi F, Khalafalla F, Dimmeler S, Fernandez-Aviles F, Sussman MA Mechanisms of Cardiac Repair and Regeneration.Circ. Res. 2018 Apr 13 122(8):1151-1163.

Gude NA, Firouzi F, Broughton KM, Ilves K, Nguyen KP, Payne CR, Sacchi V, Monsanto MM, Casillas AR, Khalafalla FG, Wang BJ, Ebeid DE, Alvarez R, Dembitsky WP, Bailey BA, van Berlo J, Sussman MA Cardiac c-Kit Biology Revealed by Inducible Transgenesis. Circ. Res. 2018 Jun 22 123(1):57-72. Epub 2018 Apr 10

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA Cardiomyocyte Regeneration: A Consensus Statement. Circulation 2017 Aug 15 136(7):680-686. Epub 2017 Jul 06

Broughton KM, Sussman MA Myocardial Regeneration for Humans - Modifying Biology and Manipulating Evolution. Circ. J. 2017 Jan 25 81(2):142-148. Epub 2016 Dec 27

Kulandavelu S, Karantalis V, Fritsch J, Hatzistergos KE, Loescher VY, McCall F, Wang B, Bagno L, Golpanian S, Wolf A, Grenet J, Williams A, Kupin A, Rosenfeld A, Mohsin S, Sussman MA, Morales A, Balkan W, Hare JM Pim1 Kinase Overexpression Enhances ckit Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine. J. Am. Coll. Cardiol. 2016 Dec 06 68(22):2454-2464.

Samse K, Hariharan N, Sussman MA Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase. Pharmacol. Res. 2016 Jan 103:13-6. Epub 2015 Nov 10

Samse K, Emathinger J, Hariharan N, Quijada P, Ilves K, Völkers M, Ormachea L, De La Torre A, Orogo AM, Alvarez R, Din S, Mohsin S, Monsanto M, Fischer KM, Dembitsky WP, Gustafsson ÅB, Sussman MA Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells. J. Biol. Chem. 2015 May 29 290(22):13935-47. Epub 2015 Apr 16

Anderson ME, Goldhaber J, Houser SR, Puceat M, Sussman MA Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ Res 2014 Jul 18 115(3):335-8. Epub 2014 Jun 16

Mohsin S, Wu JC, Sussman MA Predicting the future with stem cells. Circulation 2014 Jan 14 129(2):136-8. Epub 2013 Nov 18

Mohsin S, Khan M, Nguyen J, Alkatib M, Siddiqi S, Hariharan N, Wallach K, Monsanto M, Gude N, Dembitsky W, Sussman MA Rejuvenation of human cardiac progenitor cells with Pim-1 kinase. Circ Res 2013 Oct 25 113(10):1169-79. Epub 2013 Sep 17

Siddiqi S, Sussman MA Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase. Expert Rev Cardiovasc Ther 2013 Aug 11(8):949-57.

Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci U S A 2013 Apr 9 110(15):5969-74. Epub 2013 Mar 25

Williams AR, Hatzistergos KE, Addicott B, McCall F, Carvalho D, Suncion V, Morales AR, Da Silva J, Sussman MA, Heldman AW, Hare JM Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation 2013 Jan 15 127(2):213-23. Epub 2012 Dec 05

Tufan H, Zhang XH, Haghshenas N, Sussman MA, Cleemann L, Morad M Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. J Mol Cell Cardiol 2012 Nov 53(5):695-706. Epub 2012 Aug 19

Cottage CT, Neidig L, Sundararaman B, Din S, Joyo AY, Bailey B, Gude N, Hariharan N, Sussman MA Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells. Stem Cells 2012 Nov 30(11):2512-22.

Quijada P, Toko H, Fischer KM, Bailey B, Reilly P, Hunt KD, Gude NA, Avitabile D, Sussman MA Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res 2012 Jun 22 111(1):77-86. Epub 2012 May 22

Sundararaman B, Avitabile D, Konstandin MH, Cottage CT, Gude N, Sussman MA Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase. Circ Res 2012 Apr 27 110(9):1169-73. Epub 2012 Mar 22

Ruller CM, Tabor-Godwin JM, Van Deren DA, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R Neural stem cell depletion and CNS developmental defects after enteroviral infection. Am J Pathol 2012 Mar 180(3):1107-20. Epub 2011 Dec 31

Mohsin S, Siddiqi S, Collins B, Sussman MA Empowering adult stem cells for myocardial regeneration. Circ Res 2011 Dec 9 109(12):1415-28.

Fischer KM, Cottage CT, Konstandin MH, Völkers M, Khan M, Sussman MA Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling. J Mol Cell Cardiol 2011 Oct 51(4):554-8. Epub 2011 Jan 19

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res 2010 Apr 16 106(7):1265-74. Epub 2010 Mar 04

Cottage CT, Bailey B, Fischer KM, Avitable D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res 2010 Mar 19 106(5):891-901. Epub 2010 Jan 14

Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation 2009 Nov 24 120(21):2077-87. Epub 2009 Nov 09

Bailey B, Izarra A, Alvarez R, Fischer KM, Cottage CT, Quijada P, Díez-Juan A, Sussman MA Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med 2009 Nov 4(6):823-33.

Sussman MA Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther 2009 Aug 7(8):929-38.

Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci U S A 2008 Sep 16 105(37):13889-94. Epub 2008 Sep 10

Fransioli J, Bailey B, Gude NA, Cottage CT, Muraski JA, Emmanuel G, Wu W, Alvarez R, Rubio M, Ottolenghi S, Schaefer E, Sussman MA Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 2008 May 26(5):1315-24. Epub 2008 Feb 28

Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 2007 Dec 13(12):1467-75. Epub 2007 Nov 25

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 2004 Mar 5 94(4):514-24. Epub 2004 Jan 15

Sussman MA, Anversa P Myocardial aging and senescence: where have the stem cells gone? Annu Rev Physiol 2004 66:29-48.

 

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